Advanced Seminars in Behavioral Neuroendocrinology - Brain Stress Circuitry: Orexin Connections
Summers
SN2ACKS: Systems and Neuroscience Networks Advanced Communication of Knowledge Seminars
Formerly: Advanced Seminars in Behavioral Neuroendocrinology

Brain Stress Circuitry: Orexin Connections
Spring 2024
end
Date Speaker
streaming video
Title of the 1o Journal Paper Authors year,
journal
volume:
pages
food
Jan 17
UCL
173
Cliff
Scheduling

Organization of your Talk

Seminar Success Guide

Full USD Syllabus for the Seminar course Brain Stress Circuitry: Orexin Connections

CH Summers 2024 Handouts
Jan 24
UCL
173
Cliff
Storytelling is at the Heart of Science

How to chose a paper, What makes a good talk, Guide to Seminar Design

CH Summers 2024
:
:
Feb 21
UCL
173
Cliff
Summers
The role of the orexin system in stress response

Background papers:
W Giardino, L de Lecea 2014 Current Opinion in Neurobiology 29: 103–108 Hypocretin (orexin) neuromodulation of stress and reward pathways

PL Johnson, A Molosh, SD Fitz, WA Truitt, A Shekhar 2012 Progress in Brain Research 198: 133-161 Orexin, stress, and anxiety/panic states
D Sargin 2019
Neuropharmacology
154:
68–78
Megan
Feb 28
UCL
173
Megan
John
Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking


Background papers:
CS Thomas, A Mohammadkhani, M Rana, M Qiao, C Baimel, SL Borgland, 2024 Neuropsychopharmacology 47: 728-740 Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours


LW Hung, S Neuner, JS Polepalli, KT Beier, Matthew Wright, JJ Walsh, EM Lewis, L Luo, K Deisseroth, G Dölen, RC Malenka 2017 Science 357: 1406–1411 Gating of social reward by oxytocin in the ventral tegmental area

G Giannotti
F Mottarlini
JA Heinsbroek
MR Mandel
MH James
J Peters

2022,
Translational Paychiatry
12: 432
1-11
Brylie
Mar 6
UCL
173
Morgan
Rothschadl
Selective orexin 1 receptor antagonist SB-334867 aggravated cognitive dysfunction in 3xTg-AD mice
Background papers:
J-E Kang, MM Lim, RJ Bateman, JJ Lee, LP Smyth, JR Cirrito, N Fujiki, S Nishino, DM Holtzman 2009 Science 326: 1005-1007 Amyloid-ß dynamics are regulated by orexin and the sleep-wake cycle

Yi-Ying Li, Kai-Yue Yu, Yu-Jia Cui, Zhao-Jun Wang, Hong-Yan Cai, Ji-Min Cao, Mei-Na Wur 2023 Neurobiology of Aging 124: 71-84 Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid ß metabolism
W-R Gao, X-H Hu, K-Y Yu, H-Y Cai, Z-J Wang, Lei Wang, M-N Wu 2023
Behavioural
Brain
Research
438: 114171:
1–10
Cliff
Mar 27
UCL
173
Brylie
Hartwig
Blockade of corticotropin-releasing factor receptor 1 in the central amygdala prevents cocaine-seeking behaviour induced by orexin-A administered to the posterior paraventricular nucleus of the thalamus in male rats


Background papers:
D Rodaros, DA Caruana, S Amir, J Stewart, 2017 Neuroscience 150: 8–13 Corticotropin-releasing factor projections from limbic forebrain and paraventricular nucleus of the hypothalamus to the region of the ventral tegmental area


JJ Olney, M Navarro, TE Thiele 2017 Alcholism: Clinical and Experimental Research 41: 551–561 The role of orexin signaling in the ventral tegmental area and central amygdala in modulating binge-like ethanol drinking behavior

A Matzeu
R Martin-Fardon

2021,
J Psychiatry Neurosci
589:
E459-E471
Leighton
Apr 3
UCL
173
Leighton
Ledesma
Amygdalar CB2 cannabinoid receptor mediates fear extinction deficits promoted by orexin-A/hypocretin-1


Background papers:
I Raïch, J Biel Rebassa, J Lillo, A Cordomi, R Rivas-Santisteban, A Lillo, I Reyes-Resina, R Franco, G Navarro, 2022 International Journal of Molecular Sciences 23: 1–19 Antagonization of ox1 receptor potentiates cb2 receptor function in microglia from appsw/ind mice model


Hye Ji J. Kim 1, Ayat Zagzoog 1, Costanza Ceni, R Ferrisi, N Janz, RB Laprairie 2023 Brain Sciences 182: 1574–1588 Dual cannabinoid and orexin regulation of anhedonic behaviour caused by prolonged restraint stresss

O Gunduz-Cinar, KP MacPherson, R Cinar, J Gamble-George, K Sugden, B Williams, G Godlewski, TS Ramikie, AX Gorka, SO Alapafuja, SP Nikas, A Makriyannis9, R Poulton10, S Patel4, AR Hariri, A Caspi, TE Moffitt, G Kunos, A Holmes1 2013 Molecular Psychiatry 18: 813-823 Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

M Ten-Blanco
A Flores
I Pereda-Perez
F Piscitelli
C Izquierdo-Luengo
L Cristino
J Romero
Cecilia J Hillard
R Maldonado
V Di Marzo
F Berrendero

2024,
Biomedicine & Pharmacotherapy
149: 112925:
1-12
Morgan
Brain Stress Circuitry: Orexin Connections Take Home Messages
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Last Semester (Fall 2020): Endocannabinoids